The paper investigates the contribution of the automotive industry to the domestic economy from the point of view of regional development. This research seeks to provide an overview of how the center-peripheral location structure and the position of the global automotive supply chain affect the economic role of the industry, as well as automotive-related activities. Therefore, this paper examines the core (Germany, France and Italy) and the semi-peripheral countries (Spain, Portugal, Czech Republic, Hungary, Poland, Romania and Slovakia) in Europe comparing the results to previous outcomes. The aim of the study is to compare the automotive industry’s spillover effect between core and peripheral countries in order to investigate whether peripheral countries are lagging behind in this area. Therefore, the backbone of the study is the creation of a usable statistical framework to measure automotive spillovers in the countries examined.